Accreditations & Reliability DNA Test
Accreditation is a recognition of a service in a given field. It makes it possible to highlight the competence of an organization and reflects a mandatory process within the framework of a regulation.
Accreditation is based on references and standards defining requirements in terms of technical competence and the implementation of a management system.
The International Organization for Standardization (ISO) is a non-governmental organization which aims to produce international standards in the industrial and commercial fields called ISO standards.
ISO standards are useful to industrial and economic organizations of all kinds, in both public and private sectors, and ultimately serve the interests of the general public when acting as consumer and user .
The ISO / IEC 17025 Standard establishes general requirements for the competence of testing and calibration laboratories.
It defines a certain number of requirement criteria as regards to the competence of the personnel, the procedure of the analysis, the maintenance of the equipment, as well as the organisation of the general processes used to generate the data .
The use of this standard promotes cooperation between laboratories and other organisations. It facilitates the exchange of information and the sharing of experience, and helps to harmonise procedures.
Laboratories must therefore ensure that their working methods guarantee control over their operations and the reliability of their data. This international reference thus demonstrates the capacity of laboratories to produce reliable results while respecting quality standards and is widely recognised by different countries in the world.
Accreditations help laboratories provide services with confidence and attract new clients. It demonstrates that a laboratory has the skills necessary to manage and carry out the activities defined in its scope of accreditation for a given program.
The reliability of a DNA test
When you want to do a DNA test, the question of reliability always arises.
How can you be sure that the results provided by the laboratory are reliable? The question is all the more important since it usually has important consequences in people's lives.
So several factors go into the confidence you can bring to your results.
But it is always possible to use non-standard samples, less reliable but which can provide a solution if the saliva sample is not possible.
Laboratory accreditation ensures that analytical methods comply with standards corresponding to DNA treatments and thus promise reliable results. In this sense, the comparison of profiles can only rarely suffer irregularities since it is checked several times and generally processed by two teams who must note the same result .
For the most part, if an error is found, it happens on the use of samples that do not correspond to the customer's request, such as an inversion in the declarations of the participants and their samples.
Therefore be sure to define your requests at your statement and organise samples to avoid uncertainty in the analysis.
Accreditation of laboratories
It is very important before ordering a test to contact your laboratory to explain your personal situation. Genetics is a very unique thing that concerns your privacy and your family relationship , so any doubt or assumption can drastically change the choice of test and its reliability . It is therefore very important to be aware of the risks and especially to understand what the test can bring you.
For example :
A paternity search between a father and a daughter could logically be done using a simple paternity test. But if the paternity doubt relates to another man from the same family as the father (such as a brother) then both alleged fathers must participate in the test. If one of the two cannot participate then the test cannot be done. If the mother of the daughter participates in the test we can do it without the second father, but with reduced reliability.
The effectiveness of a test depends on your declaration , without prior advice you will not be able to be sure of the reliability of your results. We offer tools on infotestadn.com that will help you better understand DNA testing. If you do not find the information about yourself you can always contact us
Contacting the laboratory is also recommended.
Declaration of participants
All DNA tests are not equal on the odds ratio they offer , and depending on the basic situation several tests are possible and some more reliable than others.
In general, it is always advisable to do DNA tests directly with the person concerned . Therefore the result will be unequivocal and you would have a simple and clear answer to your question.
The type of DNA Test
Paternity test :
If the father is available, always try to test with him. The reliability is 100% for a negative result and 99% for a positive result. He will then give you a clear answer on the biological link between the two participants: Paternity Test
Maternity test :
If the mother is available, always try to test with her. The reliability is 100% for a negative result and 99% for a positive result. He will then give you a clear answer on the biological link between the two participants: Maternity Test
The Y Chromosome test :
The Y chromosome test allows with certainty of defining whether two men are of the same paternal line. Since this Y chromosome is exactly the same from father to son, the comparison gives a reliability of 100% for a negative result and 99% for a positive result: Y chromosome test
The X Chromosome test:
The genetic analysis of Chromosome X gives the possibility of a search for paternity between sisters. The comparison of this chromosome inherited from the father must necessarily be identical between biological sister. Thus the relationship can be precisely determined with a positive or negative answer. In addition, this research can also be applied between the paternal grandmother and her granddaughter: X chromosome test
The Mitochondrial DNA test :
The mitochondrial DNA test allows with certainty of defining whether two people are issues from the same maternal line. Since Mitochondrial DNA is transmitted identically from the mother to all her children, which gives a reliability of 100% for a negative result and 99% for a positive result: Mitochondrial DNA Test
The Prenatal Paternity Test :
The particularity of this test is that you have no other option than to test the mother and the presumed father to define the biological link with the fetus. But because of this, since the comparison is direct, the reliability remains the same as for the simple paternity test: Prenatal paternity test
The tests that we recommend to focus on:
If the situation does not allow for a test to be done directly with the person concerned, you can still do indirect DNA tests with members of your family to determine a biological relationship.
But please keep in mind that indirect tests are based on probabilities and statistics which greatly reduce the reliability in expressing the results. This does not mean that the tests can be wrong, it means that depending on the situation they will not be able to determine with sufficient precision a relationship between participants. Which could in some cases not answer the question of the relationship.
In this sense, the reliability of indirect tests will depend on the initial family situation. and the number of test participants . Because the more genetic information the laboratory has, the easier it will be to determine a biological relationship between two or more participants.
The Sibling DNA test :
To increase the reliability of a sibling test, you must clearly specify the target, according to which you will determine a search for siblings or half-siblings. In addition, it is always recommended to compare people of opposite sexes . And if possible to always be able to include the mother (s) in the test : Sibling DNA test
The Avuncular Test (Uncle and Aunt) :
To increase the reliability of an avuncular test, you must already be sure of the biological relationship between the intended parent and the sister or uncle . And always if possible include the mother of the child in the test : Avuncular test
The Grandparents DNA test :
To increase the reliability of a grandparent DNA test, you must already be sure of the biological relationship between the intended parent and their own biological parents . In addition, both grandparents must participate in the test with the child. And always if possible include the mother of the child in the test : Parentage testing Grandparents
Indirect relationship tests:
Reliable results are not dependent on the sample type, but not all samples provide enough reliable genetic information to do a DNA test.
The first difficulty for the laboratory is to extract the DNA present on the sample in order to analyse it. In this the use of oral swabs provide great reliability on the DNA extraction if the instructions have been followed correctly.
The type of DNA sample
How can you check the DNA collection ?
In the situation where you do not have control over the collection of the samples and there is doubt about the follow-up of the instructions by the participants. You have the possibility of calling on a doctor so that he can vouch for the follow-up of the procedure.
Before ordering, you can therefore contact a doctor in the country in question in order to let him know about your approach. The doctor can receive the kit directly from the laboratory and then call the participants to take the samples.
In this sense supports the doctor to verify the identity of the test participants, s' ensures follow the instructions of samples and documents necessary for the laboratory. In addition, the doctor can take care of the return of samples with the carrier.
This approach assures you :
- a rigorous instructions levies,
- verification of the identity of the participants ,
- of course reliability in the results .
Because the doubt of a possibility on an exchange of samples or a dishonest maneuver is ruled out.